Glucovance 500/5mg Tablet contains metformin hydrochloride 500mg combined with glibenclamide 5mg. This dual-action medication manages type 2 diabetes mellitus in patients with insufficient glycemic control on single-agent therapy. Uses Glucovance 500/5mg is primarily prescribed as add-on therapy with diet and exercise for adult type 2 diabetes patients struggling with hyperglycemia control using metformin alone. It’s effective when single medication fails to achieve target blood glucose levels based on complementary mechanisms of action. Benefits Provides enhanced reduction in blood glucose levels compared to monotherapy Maintains glycated hemoglobin closer to normal ranges Combines two proven antidiabetic mechanisms in one tablet Improves patient compliance with simplified dosing Reduces risk of diabetes-related complications Offers cost-effective dual therapy option Better glycemic control than either agent alone How It Works Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues. Glibenclamide stimulates insulin secretion from pancreatic beta cells and may increase tissue sensitivity to insulin. Together these complementary effects optimize blood sugar control throughout the day. Dosage Patient Category Initial Dosage Maximum Daily Dosage Adults 1 tablet twice daily 4 tablets daily Elderly 1 tablet daily As per doctor’s advice Take with meals to reduce gastrointestinal side effects and optimize glucose control. Follow physician instructions for dosage adjustments. Duration of Action Glucovance begins lowering blood glucose within 2-3 hours of administration. Metformin effects peak at 4-6 hours while glibenclamide peaks at 2-4 hours. Combined action provides 12-hour glucose control with twice-daily dosing. Full therapeutic benefits typically observed after 2-4 weeks of consistent use. Side Effects Common side effects include nausea, diarrhea, abdominal discomfort, and metallic taste from metformin. Glibenclamide may cause hypoglycemia, weight gain, and dizziness. Some patients experience headache or skin reactions. Serious but rare effects include lactic acidosis requiring immediate medical attention. Warning May cause hypoglycemia, especially when meals are skipped or during excessive exercise. Monitor blood glucose levels regularly. Use with caution in liver or kidney dysfunction. Not appropriate for type 1 diabetes or diabetic ketoacidosis. Discontinue before surgery or radiologic procedures using iodinated contrast media. Pregnancy and Breastfeeding Glucovance is not recommended during pregnancy as insulin therapy is preferred for better glycemic control and fetal safety. The medication passes into breast milk and may affect nursing infants. Consult healthcare provider for alternative diabetes management during pregnancy and breastfeeding. Interaction Alcohol increases risk of lactic acidosis and hypoglycemia Beta-blockers may mask hypoglycemic symptoms Certain antibiotics and antifungals alter glucose control Diuretics may worsen hyperglycemia Corticosteroids reduce antidiabetic effectiveness NSAIDs may affect kidney function when combined with metformin Precaution Stay well-hydrated while taking Glucovance. Avoid excessive alcohol consumption. Monitor kidney and liver function regularly during treatment. Inform doctors about Glucovance use before any medical procedures. Carry glucose tablets or candy to treat low blood sugar episodes. Regular blood glucose monitoring is essential. Important Information Glucovance works best when combined with healthy diet and regular exercise. Never share tablets with others even if they have similar symptoms. Report any muscle pain, unusual fatigue, or respiratory issues immediately as these may indicate lactic acidosis. Maintain regular follow-up appointments for monitoring treatment effectiveness and adjusting dosage. Product Image Gallery Customer questions & answers Have a question about this product? Your question * Name * Email * Notify me when answered. Recent Popular Unanswered There are no questions yet. Be the first to ask a question about this product. 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Supply Duration 1 Month Supply — — — — — — — 1 Month and 20 Days Supply — — Primary Use For managing type 2 diabetes mellitus in adults. It's particularly effective for patients whose blood glucose levels are not adequately controlled with metformin or glibenclamide alone. — — — — — — — Used for the management of type 2 diabetes mellitus to control blood sugar levels. — — Key Benefits Provides dual mechanism blood glucose control — — — — — — — Helps lower blood glucose levels, Improves insulin sensitivity — — Active Ingredients Metformin (500mg), Glibenclamide (5mg) — — — — — — — Metformin Hydrochloride (500mg) — — Vegan Friendly ✓ — — — — — — — ✓ — — Quality Standards — — — — — — — — ✓NAFDAC Approved — — Dosage 1 Tablet Twice Daily — — — — — — — 1 tablet twice daily with meals (as prescribed) — — Brand MERECK — — — — — — — HOVID — — Product Form Tablet — — — — — — — Tablet — — Age Group Adults — — — — — — — Adults — — Gender Unisex — — — — — — — Unisex — — Country of Origin FRANCE — — — — — — — MALAYSIA — — Storage Instructions Store below 30°C — — — — — — — Hovid Bhd — — ▼ Show More ▲ Show Less ← Swipe to compare → Selected with Care, Just for You Forxiga 5mg Tablet (Dapagliflozin) x30₦48,000.00Rated 0 out of 5 Forxiga 5mg Tablet treats type 2 diabetes mellitus as monotherapy... 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